Australian Brand Long-R3-IGF-1(Suspended in Benzyl Alcohol) 1mg

Background:
Long Arg³ Insulin-like Growth Factor-I (Long-R³-IGF-I) is an 83 amino acid analog of  IGF-I comprising the complete IGF-I sequence with the substitution of an Arg for the Glu at position 3 (hence R³), and a 13 amino acid extension peptide at the N-terminus. Long-R3-IGF-I is significantly more potent than IGF-I in vitro. The enhanced potency is due to the markedly decreased binding of Long-R³-IGF-I to IGF binding proteins which normally inhibit the biological actions of IGFs.

Description:
Recombinant Human Long-R³-IGF-I produced in E. coli is a single, non-glycosylated, polypeptide chain containing 83 amino acids and having a molecular mass of 9111 Dalton.

Biological activity: The ED50, calculated by the dose-dependant proliferation of murine BALB\C 3T3 cells is less then 1.0 ng/ml, corresponding to a specific activity of 1.0 x 10⁶ IU/mg. For most in-vitro applications, Long-R³-IGF-I exerts its biological activity in the concentration range of 0.2-20 ng/ml.